Oh man, "S" was tough, as there were a bunch of one-hit wonders to choose from. I decided to go with the 80s classic by Thomas Dolby. I think I was in the 3rd or 4th grade when this song came out in 1982. The song was a big hit here in the States, but I don't think it did much in his home country in the U.K.
The song is about a woman that confuses him by being overly complex. She probably rejected him and now he's trying to make sense of why she would do such a thing. It's enough to drive him crazy. I'm not really sure. But the sound is typical of the 80s synth pop New Wave sound that took America by storm.
What's fun about this song is how it samples some actual scientist yelling "Science!" In fact, if you yell it in a public place, a bunch of late 30 and early 40 year olds will know exactly what you're talking about.
Although "She Blinded Me With Science" remains Thomas Dolby's only big hit, he's stayed very active in the music industry. In addition to continuing to release albums, he has composed and performed music for movies, video games, and is even a professor of arts at John Hopkins.
A big myth surrounding Thomas Dolby is that he's the son of Dolby Laboratory's Dr. Ray Dolby (who invented that system behind your awesome surround sound home movie theater experience). He's not. Dr. Dolby actually does have a son by the same name, who is also an author.